Message from the Chair
Welcome to the Department of Chemistry and Biochemistry at UCSD
The Department of Chemistry and Biochemistry at UCSD is a great department that just keeps
getting better. In less than 50 years, UCSD and the Department of Chemistry and Biochemistry
have established a reputation as leading centers for research and teaching in the United
States and worldwide.
The National Research Council recently ranked UCSD as one of the top ten PhD-granting universities.
The Institute for Scientific Information ranked our department sixth in the nation for "High Impact
U.S. Universities, 2001-2005". The 2005 US News and World Report ranking of "Best Graduate Schools"
listed our program in Biochemistry as seventh in the nation. Of course we're also proud that Newsweek
magazine named UCSD as the 'hottest' place to do science in 2005. Our distinguished faculty includes
members of the National Academy of Sciences, the Institute of Medicine, Howard Hughes Medical Institute
investigators, and Nobel Prize-winner Mario Molina and Roger Tsien.
We build on our established strengths in two ways: (1) through continued growth, and (2) through
innovation at the dynamic interfaces between chemistry and other scientific disciplines, including
biology, medicine, physics, earth and atmospheric sciences, and engineering. The UCSD campus continues
to expand rapidly and includes cutting-edge and interdisciplinary research centers such as the Scripps
Institution of Oceanography, the San Diego Supercomputer Center, the California Institute for
Telecommunications and Information Technology, and the Center for Theoretical Biophysics. Not only
is UCSD one of the most rapidly growing public universities in the nation, but our department is
one of the highest impact in the nation. Student enrollments in both the undergraduate and graduate
program are increasing each year; we now award more B.S., M.S. and Ph.D. degrees than any other
department in the nation (Chemical & Engineering News, July 2006).
UCSD is located at the epicenter of a prestigious La Jolla research community. Collectively with
our neighboring research institutes and industrial laboratories, the critical mass of "science
on the mesa" provides a tremendous research climate that offers opportunities and resources found
nowhere else in the world. In addition to the Salk, Burnham and Scripps Research Institutes, the
local region is home to a dynamic biotech industry recently referred to as "Biotech Eden" by
Chemical & Engineering News.
Our department mirrors this dynamic interdisciplinary environment, with research interests spanning
biochemistry, biophysics, inorganic, organic, physical and theoretical chemistry, surface and materials
chemistry, and atmospheric and environmental chemistry. State-of-the-art facilities and equipment
support our research and educational programs. Our students and postdocs are equally diverse, and
enter the work force in a breadth of areas, including academia, national laboratories, biotech and
other industries.
As you browse through our Web site, I hope you will develop a sense of why we are proud of our
past achievements and why we are optimistic and excited about our future.
Robert E. Continetti, Chair
Computational Chemistry and Biophysics
Macromolecular, cryoelectron microscopy and three-dimensional, image-reconstruction techniques.
Experimental Atmospheric Chemistry
Chemical Education: Development of context-rich curriculum; Use of collaborative learning strategies in large lectures; Communication of chemistry
Natural product synthesis/biosynthesis, Biological chemistry and enzymology, Metabolic engineering.
Bioinorganic and coordination chemistry. Metalloprotein inhibitors and supramolecular materials.
Dissociation dynamics of transient species, three-body reaction dynamics, novel mass-spectrometric methods
Materials chemistry, surface kinetics of metals/semiconductors, CVD, photo-induced deposition, thin-film spectroscopy.
Science and Math Initiative/California Teach; problem-based learning; the use of computer multimedia for science instruction
Biochemistry: phospholipase A2, signal transduction in macrophages, lipid maps, prostaglandin regulation, mass spec of lipids and proteins.
Biomimetic Chemistry, Molecular Imaging, Electrochemistry
Protein Tyrosine Phosphatase, Dual=specific Phosphatase, PTEN
Fibroblast Growth Factor Receptors (FGFRs) in Human Cancer
Biochemistry, Chemical Biology, Mass spectrometry; Harvesting genomic information for therapeutics.
Inorganic and Organometallic Chemistry: Synthesis, Small Molecule Activation and New Transformations.
Physical organic chemistry; photochemistry; nanoscience of organized arrays.
Electron Transport in Condensed Phases. Dissipation and Relaxation Processes. Non-equilibrium Open Quantum Systems. Molecular Electronics.
Biochemistry and biophysics: transcription, signaling, pre-mRNA splicing, mRNA transport, protein-protein, protein-DNA and protein-RNA interactions
Mechanisms of bacterial and protozoan pathogenesis, and host response against infectious microbes.
Bioorganic chemistry, Supramolecular Chemistry, Bionanotechnology, Materials, Synthesis
Chemical synthesis; synthesis-oriented organic chemistry; methods development; synthesis design; total synthesis of natural products.
RNA as a Drug Target.                                                 
Biochemistry: signaling, transcription, computational network; stress and immune responses, apoptosis, proliferation
Biophysical chemistry: protein structure, dynamics and folding; 2, 3 and 4D NMR spectroscopy; PCR; equilibrium and kinetic-fluorescence, absorbance and circular dichroism spectroscopies
Biochemistry & Biophysics: ribosome structure, function and dynamics; discovery of novel antibiotics
Biophysical chemistry: Spectroscopic studies of membrane protein folding and dynamics
Structure, function, dynamics and thermodynamics of protein-protein interactions: NMR, mass spectrometry and kinetics
Inorganic, materials, and physical chemistry: electron transfer, catalysis, fixation and utilization of carbon dioxide.
STM/STS of gate oxides on compound semiconductors and adsorbates on organic semiconductor
Theoretical chemical physics: non-equilibrium statistical mechanics;stochastic processes; nonlinear phenomena; complex systems; condensed matter.
Experimental physical chemistry: photochemistry and photobiophysics; pico- and femtosecond lasers
Statistical mechanics and computational chemistry, with applications to biological systems
Physical Chemistry: Gas Phase Chemical Kinetics and Photochemistry; Chemistry of Atmospheric Aerosols; Air Pollution in Megacities of the Developing World
Organic chemistry of marine natural products, synthesis, NMR, and biomedical applications
Biochemistry: Evolution of catalytic RNAs, the Origin of Life
Biochemistry: Function and structural changes of the protein complexes involved in synaptic plasticity.
Total Synthesis and Chemical Biology of Natural and Designed Molecules
Organotransition metal; organic; physical organic; bioorganometallic; synthetic; and inorganic chemistry
NMR structural studies of proteins in membranes and other supramolecular assemblies
Theoretical chemical physics of complex interfaces of relevance to the environment
Physical-organic chemistry: stereoelectronic effects; hydrogen bonding; isotope effects; ionic solvation
The application of analytical chemistry to forensic, environmental and industrial chemistry, then bridge these experiences into the classroom. This also includes the role technology and instrumentation play in discovery and problem solving.
Environmental, physical/analytical chemistry: gas/particle processes of tropospheric significance; mass spectrometry; laser-based analysis techniques.
Inorganic chemistry: Small-molecule crystallography, synthesis of transition metal/p-block clusters
Nanomaterials: porous silicon, chemical and biological sensors, biomaterials, electrochemistry
Chemical education: development of computer-based multimedia to assist student learning of complex scientific processes and concepts
Experimental physical chemistry: photochemistry; laser spectroscopy; reaction dynamics of vibrationally excited molecules
Physical chemistry; Optical and magnetic spectroscopy; Fundamental studies of charge transport and solvation; Applications to energy conversion and energy storage.
Structure, Function, Dynamics, and Localization of PKA as a Prototype for the Protein Kinase Superfamily.
Bioinorganic and biophysical chemistry; Metalloprotein structure, function and biosynthesis; Biomaterials
Synthetic, Medicinal, Bioorganic and Biological Chemistry, Methods and Strategies in Natural Products Chemistry
Atmospheric chemistry: physical chemistry of isotope effects; solar system formation
Structure and Function of Introns and Retroelements
Ligand-nucleic acid interactions; Antiviral and antibacterial agents; Fluorescent nucleosides and nucleotides; Cellular delivery vehicles
Inorganic chemistry: polymer chemistry; nanomaterials.
Chemical biology; design, synthesis, and application of molecular probes of biological function
Environmental toxicology: The role of environmental and chemical toxicants on gene expression
Laboratory of Structural Biochemistry: X-ray Crystallography and Cryo-Electron Microscopy of DNA Binding Proteins and Membrane Proteins
Inference of gene regulatory networks and determination of protein specificity
Physical chemistry: calculations of the dynamics of complex systems; theoretical geochemistry
Chemical education, Bioorganic chemistry
Organic chemistry: studies of stereochemistry, both in a molecular and a supramolecular sense.
Bioorganic Chemistry, Molecular Self-Assembly, Molecular Synthesis, Materials Chemistry, Bionanotechnology
Peter B. Dervan, Professor
Dr. Roy Wollman
Dr. Mohammad Seyedsayamdost