Corbett, Kevin
Molecular mechanisms of recombination and chromosome segregation in meiosis and mitosis
Education
2005 PhD,
Molecular Cell Biology,
University of California, Berkeley
2000 BS,
Biochemistry,
University of Virginia
Research Interests
Our laboratory is focused on the molecular mechanisms of chromosome segregation in mitosis and meiosis. We use biochemistry, X-ray crystallography, and cryo-electron microscopy to probe the structure, function, and interactions between proteins involved in meiotic chromosome pairing, crossover initiation and maturation, and chromosome segregation. We also study a novel second messenger-based bacteriophage immunity pathway in bacteria, that incorporates eukaryotic-like HORMA domains in a foreign protein-sensing role.
Interdisciplinary interests
Biophysics
Macromolecular Structure
Cellular Biochemistry
Selected Publications
- Lau R.K., Ye Q., Patel L., Berg K.R., Mathews I.T., Watrous J.D., Whiteley A.T., Lowey B., Mekalanos J.J., Kranzusch P.J., Jain M., Corbett K.D. "Structure and mechanism of a cyclic trinucleotide-activated bacterial endonuclease mediating bacteriophage immunity", BioRxiv, 2019, 694703
- Patel L,Kang R,Rosenberg SC,Qiu Y,Raviram R,Chee S,Hu R,Ren B,Cole F,Corbett KD "Dynamic reorganization of the genome shapes the recombination landscape in meiotic prophase.", Nat Struct Mol Biol, 2019, Vol. 26, Issue 3, 164-174
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- Ye Q., Lau R.K., Mathews I.T., Watrous J.D., Azimi C.S., Jain M., Corbett K.D. "HORMA domain proteins and a Pch2-like ATPase regulate bacterial cGAS-like enzymes to mediate bacteriophage immunity", BioRxiv, 2019, 694695
- West AMV,Komives EA,Corbett KD "Conformational dynamics of the Hop1 HORMA domain reveal a common mechanism with the spindle checkpoint protein Mad2.", Nucleic Acids Res, 2018, Vol. 46, Issue 1, 279-292
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- Batra R,Nelles DA,Pirie E,Blue SM,Marina RJ,Wang H,Chaim IA,Thomas JD,Zhang N,Nguyen V,Aigner S,Markmiller S,Xia G,Corbett KD,Swanson MS,Yeo GW "Elimination of Toxic Microsatellite Repeat Expansion RNA by RNA-Targeting Cas9.", Cell, 2017, Vol. 170, Issue 5, 899-912.e10
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- Ye Q,Kim DH,Dereli I,Rosenberg SC,Hagemann G,Herzog F,Tóth A,Cleveland DW,Corbett KD "The AAA+ ATPase TRIP13 remodels HORMA domains through N-terminal engagement and unfolding.", EMBO J, 2017, Vol. 36, Issue 16, 2419-2434
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- Rosenberg SC,Corbett KD "The multifaceted roles of the HORMA domain in cellular signaling.", J Cell Biol, 2015, Vol. 211, Issue 4, 745-55
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- Ye Q,Rosenberg SC,Moeller A,Speir JA,Su TY,Corbett KD "TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching.", Elife, 2015, Vol. 4,
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- Kim Y,Rosenberg SC,Kugel CL,Kostow N,Rog O,Davydov V,Su TY,Dernburg AF,Corbett KD "The chromosome axis controls meiotic events through a hierarchical assembly of HORMA domain proteins.", Dev Cell, 2014, Vol. 31, Issue 4, 487-502
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- Sarangapani KK,Duro E,Deng Y,Alves Fde L,Ye Q,Opoku KN,Ceto S,Rappsilber J,Corbett KD,Biggins S,Marston AL,Asbury CL "Sister kinetochores are mechanically fused during meiosis I in yeast.", Science, 2014, Vol. 346, Issue 6206, 248-51
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