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Seth Cohen
Bioinorganic and coordination chemistry. Metalloprotein inhibitors and supramolecular materials. |
| Contact Information |
| Office: PACH 4100E |
| Phone: (858) 822-5596 |
| Fax: (858) 822-5598 |
| Email: scohen@ucsd.edu |
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| Education and Appointments |
| 1998 |
Ph.D., University of California, Berkeley
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| 1994 |
B.S/B.A, Stanford University
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| Awards and Academic Honors |
| 2008-2009 |
AAAS Roger Revelle Fellow |
| 2006-2010 |
NSF CAREER Award |
| 2004 |
Cottrell Scholar Award |
| 2002-2003 |
Hellman Fellow |
| 2001-2006 |
Chris and Warren Hellman Faculty Scholar Award |
| 1999-2001 |
N.I.H. Postdoctoral Fellow, Massachusetts Institute of Technology |
| Research Interests |
Metalloprotein Inhibitors - Bioinorganic/Medicinal Chemistry
Several metalloproteins are implicated in various diseases, including arthritis, heart disease, cancer, and others. Compounds containing ligands that chelate the catalytic metal ion in these proteins can act as effective inhibitors of potential therapeutic value. Our investigations focus on the design, synthesis, and evaluation of novel metalloprotein inhibitors based on new ligands for binding the active site metal ions.
Metal-Organic Frameworks - Inorganic/Materials Chemistry
We study the design, preparation, and properties of metal-organic frameworks (MOFs). MOFs are a fascinating new class of advanced materials that may be useful in a variety of technological applications. We use organic chemistry to modify the surface and interior of MOFs in order to tune and optimize their physical and chemical properties.
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| Primary Research Area: |
Interdisciplinary Specialties: |
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Inorganic Chemistry
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Materials
Synthesis
Biophysics
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| Selected Publications |
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Faith E. Jacobsen, Jana A. Lewis, and Seth M. Cohen, "A New Role for Old Ligands: Discerning Chelators for Zinc Metalloproteinases" J. Am. Chem. Soc. 2006, 128, 3156-3157.
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Emily Dugan, Zhenqiang Wang, Marilyn Okamura, Annette Medina, and Seth M. Cohen, "Covalent Modification of a Metal-Organic Framework with Isocyanates: Probing Substrate Scope and Reactivity" Chem. Commun. 2008, 3366-3368.
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Zhenqiang Wang and Seth M. Cohen, "Tandem Modification of Metal-Organic Frameworks via a Postsynthetic Approach" Angew. Chem. Intl. Ed. 2008, 47, 4699-4702
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Arpita Agrawal, César Augusto F. de Oliveira, Yuhui Cheng, Jennifer A. Jacobsen, J. Andrew McCammon, and Seth M. Cohen, "Thioamide Hydroxypyrothiones Supersede Amide Hydroxypyrothiones in Potency Against Anthrax Lethal Factor" J. Med. Chem. 2009, 52, 1063-1074
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Kristine K. Tanabe, and Seth M. Cohen, "Engineering a Metal-Organic Framework Catalyst using Postsynthetic Modification" Angew. Chem. Intl. Ed. 2009, 48, 7424-7427
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Zhenqiang Wang and Seth M. Cohen, "Modulating Metal-Organic Frameworks to Breathe: A Postsynthetic Covalent Modification Approach" J. Am. Chem. Soc. 2009, accepted for publication.
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