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Nathan Gianneschi
Bioorganic chemistry, Supramolecular Chemistry, Bionanotechnology, Materials, Synthesis |
| Contact Information |
| Office: PACH 6224A |
| Phone: (858) 246-0857 |
| Email: ngianneschi@ucsd.edu |
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| Education and Appointments |
| 2008 |
The Scripps Research Institute
Postdoctoral fellow
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| 2005 |
PhD, Northwestern University, IL
Chemistry
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| 1999 |
B.Sc, University of Adelaide, Australia
Chemistry (Hons)
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| Awards and Academic Honors |
| 2008 |
Camille and Henry Dreyfus Foundation New Faculty Award |
| 2006 |
ACS Young Investigator Award - Division of Inorganic Chemistry |
| 2005 |
Dow Chemical Company Foundation Fellow |
| 2004 |
Chemistry Thesis Award, Northwestern University |
| Research Interests |
The ability to control the assembly and destruction of nanoscale materials in response to specific biomolecular stimuli is expected to have a significant impact in targeted drug delivery and advanced sensor design. Our program takes a multidisciplinary approach to the development of novel, stimuli responsive supramolecular and nanoscale materials by combining synthetic organic and inorganic chemistry with biological molecules and polymers.
We seek to develop discrete nanoscale structures based on amphiphilic polymeric assemblies as potentially powerful tools in the quest for functional biohybrid materials. Because the materials we target are soft and generated from multifunctional polymers, we anticipated that these systems will be amenable to carrying a drug molecule payload as well as dyes for disease specific stimuli induced release. Indeed, a key goal of this work is to utilize soft nanoscale materials in programmed, targeted anticancer drug delivery.
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| Primary Research Area: |
Interdisciplinary Specialties: |
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Organic Chemistry
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Bioorganic
Materials
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| Selected Publications |
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Gianneschi, N. C.; Ghadiri, M. R. Design of Molecular Logic Devices Based on a Programmable DNA-Regulated Semisynthetic Enzyme. Angew. Chem. Int. Ed. 2007, 46, 3955-3958
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Gianneschi, N. C.; Masar, M. S.; Mirkin, C. A. Development of a Coordination Chemistry-based Approach for Functional Supramolecular Structures. Acc. Chem. Res. 2005, 38, 825-837
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Gianneschi, N. C.; Nguyen, S. T.; Mirkin, C. A. Signal Amplification and Detection via a Supramolecular Allosteric Catalyst. J. Am. Chem. Soc. 2005, 127, 1644-1645
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