Mishanina, Tatiana
Transcription and its regulation; RNA polymerase structure and function in bacteria and human mitochondria

Contact Information
Assistant Professor of Chemistry and Biochemistry

Office: Natural Sciences Bldg 4320
Phone: 858-246-5883
Email: tmishanina@ucsd.edu
Web: mishaninalab.ucsd.edu
Group: View group members
2014 Ph.D., Chemistry, University of Iowa
2008 B.S., Chemistry, Wichita State University
2019–present Assistant Professor, Chemistry and Biochemistry, University of California San Diego
2015–2018 Postdoctoral Fellow, Biochemistry, University of Wisconsin–Madison
2014–2015 Postdoctoral Associate, Biological Chemistry, University of Michigan
Research Interests
Our lab is interested in the underlying molecular mechanisms of gene expression in human mitochondria and bacteria. We use a combination of biochemical and structural biology approaches to study how RNA polymerase, the central enzyme in gene expression, contributes to gene regulation via transcriptional pausing; how it couples RNA synthesis to DNA replication, RNA processing and translation in mitochondria; and how we can control these processes to rationally manipulate gene expression for antimicrobials and treatments of disease. Students in the lab are trained in enzymology (e.g., kinetics, in vitro assays) and state-of-the-art structural methods (e.g., single-particle cryo-EM).
Primary Research Area
Interdisciplinary interests
Macromolecular Structure
Cellular Biochemistry

Selected Publications